Table 1.
Incidence of ON and Arteriopathy in Mice Treated with DEX with or without ASP and/or 6MP
| Strain | No. (%) | Evaluated for arteriopathy, no. | Arteriopathy positive, no. (%) | Arteriopathy negative, no. (%) | P value∗ |
|---|---|---|---|---|---|
| BALBcAnN | |||||
| DEX 4 mg (n = 56) | 0.21 | ||||
| Positive ON | 3 (5.4) | 1 | 1 (100) | 0 (0) | |
| Negative ON | 53 (94.6) | 13 | 2 (15.4) | 11 (84.6) | |
| DEX 4 mg + ASP (n = 19) | 0.17 | ||||
| Positive ON | 2 (10.5) | 2 | 2 (100) | 0 (0) | |
| Negative ON | 17 (89.5) | 2 | 0 (0) | 2 (100) | |
| DEX 8 mg (n = 54) | 0.0002 | ||||
| Positive ON | 17 (31.5) | 12 | 12 (100) | 0 (0) | |
| Negative ON | 37 (68.5) | 16 | 5 (31.3) | 11 (68.8) | |
| DEX 8 mg + ASP (n = 59) | 0.02 | ||||
| Positive ON | 8 (13.6) | 8 | 7 (87.5) | 1 (12.5) | |
| Negative ON | 51 (86.4) | 8 | 2 (25.0) | 6 (75.0) | |
| BALBcAnN total (n = 188) | <0.0001 | ||||
| Positive ON | 30 (16.0) | 23 | 22 (95.7) | 1 (4.3) | |
| Negative ON | 158 (84.0) | 39 | 9 (23.1) | 30 (76.9) | |
| BALBcJ | |||||
| DEX 4 mg (n = 137) | <0.0001 | ||||
| Positive ON | 43 (31.4) | 29 | 29 (100) | 0 (0) | |
| Negative ON | 94 (68.6) | 21 | 11 (52.4) | 10 (47.6) | |
| DEX + 6MP (n = 99) | <0.0001 | ||||
| Positive ON | 38 (38.4) | 35 | 35 (100) | 0 (0) | |
| Negative ON | 61 (61.6) | 25 | 13 (52.0) | 12 (48.0) | |
| DEX 4 mg + ASP (n = 21) | 0.14 | ||||
| Positive ON | 7 (33.3) | 4 | 4 (100) | 0 (0) | |
| Negative ON | 14 (66.7) | 3 | 1 (33.3) | 2 (66.7) | |
| BALB/cJ total (n = 257) | <0.0001 | ||||
| Positive ON | 88 (34.2) | 68 | 68 (100) | 0 (0) | |
| Negative ON | 169 (65.8) | 49 | 25 (51.0) | 24 (49.0) | |
| All Mice | |||||
| (n = 445) | <0.0001 | ||||
| Positive ON | 118 (26.5) | 91 | 90 (98.9) | 1 (1.1) | |
| Negative ON | 327 (73.5) | 88 | 34 (38.6) | 54 (61.4) | |
ASP, asparaginase; 6-MP, 6-mercaptopurine.
∗
P values for comparing the incidence of arteriopathy in ON-positive and ON-negative cases, using χ2 test (if the expected number of cases in each category is ≥5) or Fisher’s exact test (if the expected number of cases in any category is <5).