Figure 1.
Platelet levels in control and DSS-fed mice. Changes in blood levels of total platelets (A), immature platelets (C), and mature platelets (D) in mice placed on regular drinking water (WT-H2O) or 3% DSS. Representative flow cytometric analyses of mature (TO−) and immature (TO+) platelets in the different experimental groups (WT-H2O, n = 5; WT-DSS, n = 7; IL-6−/−-DSS, n = 5; IL-6−/−⇒WT, n = 5) B: The platelet populations were gated on CD41+ cells. WT, IL-6−/−, and IL-6−/−⇒WT mice were studied. ∗P < 0.001 versus WT-H2O; ∗∗P < 0.01 versus WT-DSS; and ∗∗∗P < 0.01 versus WT-DSS.