Table 1.

Baseline and 8 weeks values for serum glucose, insulin, IGF-1, IGFPB-3, HOMA-IR, and IGF-I:IGFBP-3 ratio for the HF, LF, and LFn3.

	HF n = 17	LF n = 16	LFn3¹ n = 16	P-value²
Glucose (mmol/L)
Baseline	5.98 ± 0.3	5.96 ± 0.3	5.78 ± 0.3	0.43
8 weeks	5.95 ± 0.2	5.67± 0.2	6.05 ± 0.2	0.47
P-value³	0.92	0.20	0.36
Insulin (pmol/L)
Baseline	73.6 ± 6.9	76.4 ± 6.9	70.8 ± 6.9	0.56
8 weeks	72.2 ± 7.6	73.6 ± 7.6	76.4 ± 7.6	0.60
P-value³	0.83	0.66	0.31
IGF-I (nmol/L)
Baseline	19.6 ± 1.5	19.6 ± 1.5	17.8 ± 1.5	0.24
8 weeks	19.3 ± 1.6	20.3 ± 1.6	21.4 ± 1.6^*	0.10
P-value³	0.74	0.61	< 0.001
IGFBP-3 (nmol/L)
Baseline	183.0 ± 14.4	167.1 ± 14.9	183.5 ± 14.9	0.60
8 weeks	193.0 ± 15.4	179.6 ± 16.0^*	199.9 ± 16.0^*	0.60
P-value³	0.10	0.04	0.01
HOMA-IR
Baseline	2.9 ± 0.4	3.1 ± 0.4	2.8 ± 0.4	0.42
8 weeks	2.8 ± 0.3	2.7 ± 0.3	3.1 ± 0.3	0.26
P-value³	0.66	0.19	0.31
IGF-I:IGFBP-3 ratio
Baseline	0.120 ± 0.016	0.129 ± 0.017	0.112 ± 0.017	0.42
8 weeks	0.111 ± 0.016	0.119 ± 0.016	0.123 ± 0.016	0.74
P-value³	0.20	0.13	0.13
Body Weight (kg)
Baseline	73.2 ± 2.8	73.6 ± 2.8	73.4 ± 2.8	0.83
8 weeks	72.1 ± 2.74^*	72.3 ± 2.7^*	72.7 ± 2.7^*	0.46
P-value³	< 0.001	< 0.0001	0.02

For the final analysis, 17 participants completed the high fat (HF) diet, 16 participants completed the low fat (LF) diet, and 16 participants completed the low fat + n-3 fatty acids (LFn3) diet. A general linear mixed model was used for data analysis. All values are means ± standard errors.

One subject was excluded from insulin and HOMA-IR analysis in the LFn3, thus n=15 for these endpoints.

P-value for effect of treatment across the three diets.

P-value for paired t-test comparing baseline and 8 weeks means within each diet.

8 weeks mean is significantly different from baseline mean.