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. Author manuscript; available in PMC: 2013 Jul 6.
Published in final edited form as: Physiol Behav. 2010 Oct 14;102(1):96–104. doi: 10.1016/j.physbeh.2010.09.025

Figure 4. Locomotor response of intact and gonadectomized male rats to repeated cocaine (15mg/kg) administration.

Figure 4

Animals received daily injections of 15mg/kg cocaine for 5 consecutive days and a challenge injection on day 13. Horizontal (A and C) and stereotyped (B and D) activity was recorded on days 1 (white bar and circle), 5 (grey bar and circle) and 13 (black bar and circle) for 30 min prior to injection (0 – 30 min) and 1 hour after injection (31 – 90 min). Data are presented on the left of each panel as the mean sum ± SEM of the first 30 minutes after cocaine injection and on the right of each panel as mean ± SEM in 5 min intervals; N: INT = 30 (STRCNT) – 31 (HACTV), GDX = 29. INT male rats show an increased locomotor response after repeated injections, while GDX animals do not. These results indicate that 15mg/kg of cocaine induces sensitization in INT but not in GDX male rats. * p<0.05 compared to LMA on day 1.