Table 3.
Expression of the mucin core proteins and clinicopathologic variables n (%)
| WMDA | PDA | MUA | ||||||||
| MUC2 | MUC2 | MUC2 | ||||||||
| - | + | P value | - | + | P value | - | + | P value | ||
| Median age (range), yr | 64 (32-82) | 64 (34-87) | 0.783 | 64 (35-92) | 66.5 (55-86) | 0.633 | 65 (52-88) | 71 (26-90) | 0.842 | |
| Gender | Male | 21 (33.3) | 18 (28.6) | 0.537 | 41 (45.1) | 4 (4.4) | 1.000 | 1 (1.2) | 45 (55.6) | 0.311 |
| Female | 11 (17.5) | 13 (20.6) | 42 (46.1) | 4 (4.4) | 3 (3.7) | 32 (39.5) | ||||
| Locus | Right-sided | 10 (15.9) | 10 (15.9) | 0.932 | 47 (51.6) | 6 (6.6) | 0.461 | 1 (1.2) | 40 (49.4) | 0.359 |
| Left-sided | 22 (34.9) | 21 (33.3) | 36 (39.6) | 2 (2.2) | 3 (3.7) | 37 (45.7) | ||||
| Venous invasion | Yes | 24 (38.1) | 24 (38.1) | 1.000 | 71 (79.0) | 6 (6.6) | 0.325 | 3 (3.7) | 38 (46.9) | 0.616 |
| No | 8 (12.7) | 7 (11.1) | 11 (12.2) | 2 (2.2) | 1 (1.2) | 39 (48.1) | ||||
| Lymphatic invasion | Yes | 21 (33.3) | 14 (22.2) | 0.102 | 76 (84.4) | 6 (6.7) | 0.148 | 1 (1.2) | 51 (63.0) | 1.000 |
| No | 11 (17.5) | 17 (27.0) | 6 (6.7) | 2 (2.2) | 3 (3.7) | 26 (32.1) | ||||
| Nodal metastasis | Yes | 20 (31.7) | 14 (22.2) | 0.167 | 64 (72.7) | 5 (5.7) | 0.362 | 2 (2.5) | 35 (44.3) | 1.000 |
| No | 12 (19.0) | 17 (27.0) | 16 (18.2) | 3 (3.4) | 2 (2.5) | 40 (50.6) | ||||
| TNM stage | I/II | 12 (19.0) | 17 (27.0) | 0.167 | 14 (15.6) | 3 (3.3) | 0.171 | 2 (2.5) | 38 (48.1) | 1.000 |
| III/IV | 20 (31.7) | 14 (22.2) | 68 (75.5) | 5 (5.6) | 2 (2.5) | 37 (46.8) | ||||
| dMMR | Yes | ND | 16 (17.6) | 3 (3.3) | 0.356 | ND | ||||
| No | 67 (73.6) | 5 (5.5) | ||||||||
| MUC5AC | MUC5AC | MUC5AC | ||||||||
| - | + | P value | - | + | P value | - | + | P value | ||
| Median age (range), yr | 64 (32-83) | 69 (47-87) | 0.099 | 63 (36-87) | 70 (35-92) | 0.096 | 67 (34-87) | 72 (26-90) | 0.061 | |
| Gender | Male | 26 (41.3) | 13 (20.6) | 0.677 | 22 (24.2) | 23 (25.3) | 0.919 | 23 (28.4) | 23 (28.4) | 0.371 |
| Female | 18 (28.6) | 6 (9.5) | 22 (24.2) | 24 (26.3) | 14 (17.3) | 21 (25.9) | ||||
| Locus | Right-sided | 10 (15.9) | 10 (15.9) | 0.410 | 20 (22.0) | 33 (36.3) | 0.017 | 12 (14.8) | 29 (35.8) | 0.003 |
| Left-sided | 34 (54.0) | 9 (14.3) | 24 (26.4) | 14 (15.4) | 25 (30.9) | 15 (18.5) | ||||
| Venous invasion | Yes | 34 (54.0) | 14 (22.2) | 0.757 | 38 (42.2) | 39 (43.3) | 1.000 | 16 (19.8) | 25 (30.9) | 0.224 |
| No | 10 (15.9) | 5 (7.9) | 6 (6.7) | 7 (7.8) | 21 (25.9) | 19 (23.5) | ||||
| Lymphatic invasion | Yes | 26 (41.3) | 9 (14.3) | 0.560 | 41 (45.6) | 41 (45.6) | 0.714 | 25 (30.9) | 29 (35.8) | 0.875 |
| No | 18 (28.6) | 10 (15.9) | 3 (3.3) | 5 (5.6) | 12 (14.8) | 15 (18.5) | ||||
| Nodal metastasis | Yes | 23 (36.5) | 11 (17.5) | 0.892 | 40 (45.5) | 29 (33.0) | 0.010 | 17 (21.5) | 20 (25.3) | 0.950 |
| No | 21 (33.3) | 8 (12.7) | 4 (4.5) | 15 (17.0) | 19 (24.1) | 23 (29.1) | ||||
| TNM stage | I/II | 21 (33.3) | 8 (12.7) | 0.892 | 3 (3.3) | 14 (15.6) | 0.010 | 18 (22.8) | 22 (27.8) | 0.918 |
| III/IV | 23 (36.5) | 11 (17.5) | 41 (45.6) | 32 (35.6) | 18 (22.8) | 21 (26.6) | ||||
| dMMR | Yes | ND | 3 (3.3) | 16 (17.6) | 0.003 | ND | ||||
| No | 41 (45.1) | 31 (34.1) | ||||||||
MUC: Mucin; WMDA: Well-to-moderately differentiated adenocarcinoma; PDA: Poorly differentiated adenocarcinoma; MUA: Mucinous adenocarcinoma; dMMR: Mismatch-repair deficiency; ND: Not determined; TNM: Tumor node metastasis.