Table 2.
Associations between genetic polymorphisms and colorectal adenomas n (%)
| Genotype | Cases | Controls | Crude | Adjusted3 |
| OR (95%CI) | ||||
| CYP1A1*2A | ||||
| 01 | 174 (38.2) | 388 (36.9) | 1.00 (referent) | 1.00 (referent) |
| 1 | 219 (48.1) | 508 (48.3) | 0.96 (0.76-1.22) | 0.97 (0.76-1.24) |
| 2 | 62 (13.6) | 156 (14.8) | 0.89 (0.63-1.25) | 0.86 (0.60-1.23) |
| CYP1A1*2C | ||||
| 01 | 281 (61.8) | 611 (58.1) | 1.00 (referent) | 1.00 (referent) |
| 1 | 152 (33.4) | 389 (37.0) | 0.85 (0.67-1.07) | 0.81 (0.64-1.03) |
| 2 | 22 (4.8) | 52 (4.9) | 0.92 (0.55-1.54) | 0.94 (0.55-1.60) |
| GSTM1 | ||||
| Non-null | 200 (44.0) | 506 (48.1) | 1.00 (referent) | 1.00 (referent) |
| Null | 255 (56.0) | 546 (51.9) | 1.18 (0.95-1.47) | 1.19 (0.94-1.49) |
| GSTT1 | ||||
| Non-null | 258 (56.7) | 552 (52.5) | 1.00 (referent) | 1.00 (referent) |
| Null | 197 (43.3) | 500 (47.5) | 0.84 (0.68-1.05) | 0.87 (0.70-1.10) |
| GSTM1 + GSTT1 | ||||
| 02 | 118 (25.9) | 273 (26.0) | 1.00 (referent) | 1.00 (referent) |
| 1 | 222 (48.8) | 512 (48.7) | 1.00 (0.77-1.31) | 1.04 (0.79-1.37) |
| 2 (both null) | 115 (25.3) | 267 (25.4) | 1.00 (0.73-1.35) | 1.04 (0.76-1.42) |
| NQO1 C609T | ||||
| CC | 161 (35.4) | 412 (39.2) | 1.00 (referent) | 1.00 (referent) |
| CT | 220 (48.4) | 489 (46.5) | 1.15 (0.90-1.47) | 1.18 (0.92-1.52) |
| TT | 74 (16.3) | 151 (14.4) | 1.25 (0.90-1.75) | 1.31 (0.93-1.84) |
1
Number of variant alleles;
2
Number of null genotypes;
3
Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer.