Table 4.
Associations between genetic polymorphisms and colorectal adenomas with stratification by smoking category
| Genotype |
< 20 pack-years |
≥ 20 pack-years |
Interaction (P) | ||
| n1 | OR (95%CI)2 | n1 | OR (95%CI)2 | ||
| CYP1A1*2A | |||||
| 03 | 59/207 | 1.00 (referent) | 115/181 | 2.22 (1.52-3.24) | 0.45 |
| ≥ 1 | 100/346 | 1.05 (0.73-1.53) | 181/318 | 1.95 (1.37-2.76) | |
| CYP1A1*2C | |||||
| 03 | 106/329 | 1.00 (referent) | 175/282 | 1.90 (1.41-2.56) | 0.59 |
| ≥ 1 | 53/224 | 0.76 (0.52-1.11) | 121/217 | 1.65 (1.20-2.27) | |
| GSTM1 | |||||
| Non-null | 69/264 | 1.00 (referent) | 131/242 | 1.99 (1.41-2.82) | 0.96 |
| Null | 90/289 | 1.19 (0.83-1.71) | 165/257 | 2.35 (1.68-3.29) | |
| GSTT1 | |||||
| Non-null | 89/268 | 1.00 (referent) | 169/284 | 1.74 (1.27-2.38) | 0.26 |
| Null | 70/285 | 0.74 (0.52-1.06) | 127/215 | 1.69 (1.21-2.36) | |
| GSTM1 + GSTT1 | |||||
| 04 | 39/134 | 1.00 (referent) | 79/139 | 1.87 (1.18-2.96) | 0.63 |
| 1 | 80/264 | 1.03 (0.67-1.61) | 142/248 | 1.91 (1.26-2.91) | |
| 2 (both null) | 40/155 | 0.89 (0.54-1.48) | 75/112 | 2.14 (1.34-3.43) | |
| NQO1 C609T | |||||
| CC | 52/221 | 1.00 (referent) | 109/191 | 2.23 (1.51-3.29) | 0.46 |
| CT + TT | 107/332 | 1.35 (0.93-1.97) | 187/308 | 2.51 (1.75-3.60) | |
1Number of cases/controls;
2
Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer;
3
Number of variant alleles;
4
Number of null genotypes.