Table 5.
Associations between combinations of genetic polymorphisms and colorectal adenomas with stratification by smoking category
| Genotype 1 | Genotype 2 |
< 20 pack-years |
≥ 20 pack-years |
Interaction (P) | ||
| n1 | OR (95%CI)2 | n1 | OR (95%CI)2 | |||
| CYP1A1*2A | GSTM1 | 0.44 | ||||
| 03 | Non-null | 25/87 | 1.00 (referent) | 50/95 | 1.78 (1.00-3.14) | |
| 0 | Null | 34/120 | 0.94 (0.52-1.69) | 65/86 | 2.53 (1.45-4.43) | |
| ≥ 1 | Non-null | 44/177 | 0.86 (0.49-1.50) | 81/147 | 1.82 (1.07-3.10) | |
| ≥ 1 | Null | 56/169 | 1.19 (0.69-2.05) | 100/171 | 1.92 (1.14-3.22) | |
| CYP1A1*2A | GSTT1 | 0.56 | ||||
| 03 | Non-null | 29/98 | 1.00 (referent) | 63/112 | 1.94 (1.15-3.28) | |
| 0 | Null | 30/109 | 0.95 (0.53-1.71) | 52/69 | 2.53 (1.44-4.44) | |
| ≥ 1 | Non-null | 60/170 | 1.26 (0.75-2.11) | 106/172 | 2.07 (1.27-3.39) | |
| ≥ 1 | Null | 40/176 | 0.81 (0.47-1.40) | 75/146 | 1.70 (1.02-2.82) | |
| CYP1A1*2A | GSTM1 + GSTT1 | 0.40 | ||||
| 03 | 04 | 14/42 | 1.00 (referent) | 27/60 | 1.34 (0.62-2.89) | |
| 0 | 1 | 26/101 | 0.76 (0.36-1.62) | 59/87 | 2.02 (1.00-4.07) | |
| 0 | 2 (both null) | 19/64 | 0.87 (0.39-1.94) | 29/34 | 2.46 (1.11-5.46) | |
| ≥ 1 | 0 | 25/92 | 0.83 (0.39-1.78) | 52/79 | 1.89 (0.93-3.86) | |
| ≥ 1 | 1 | 54/163 | 1.01 (0.51-2.01) | 83/161 | 1.52 (0.78-2.98) | |
| ≥ 1 | 2 (both null) | 21/91 | 0.73 (0.33-1.59) | 46/78 | 1.66 (0.81-3.40) | |
| CYP1A1*2A | NQO1 C609T | 0.76 | ||||
| 03 | CC | 20/73 | 1.00 (referent) | 43/60 | 2.55 (1.34-4.86) | |
| 0 | CT + TT | 39/134 | 1.04 (0.56-1.94) | 72/121 | 2.15 (1.20-3.86) | |
| ≥ 1 | CC | 32/148 | 0.81 (0.43-1.54) | 66/131 | 1.69 (0.94-3.04) | |
| ≥ 1 | CT + TT | 68/198 | 1.29 (0.72-2.29) | 115/187 | 2.23 (1.28-3.89) | |
| CYP1A1*2C | GSTM1 | 0.78 | ||||
| 02 | Non-null | 47/150 | 1.00 (referent) | 80/144 | 1.74 (1.13-2.69) | |
| 0 | Null | 59/179 | 1.04 (0.67-1.63) | 95/138 | 2.15 (1.40-3.31) | |
| ≥ 1 | Non-null | 22/114 | 0.63 (0.36-1.11) | 51/98 | 1.59 (0.98-2.57) | |
| ≥ 1 | Null | 31/110 | 0.94 (0.55-1.58) | 70/119 | 1.77 (1.13-2.78) | |
| CYP1A1*2C | GSTT1 | 0.11 | ||||
| 02 | Non-null | 60/151 | 1.00 (referent) | 94/170 | 1.39 (0.93-2.07) | |
| 0 | Null | 46/178 | 0.66 (0.42-1.03) | 81/112 | 1.80 (1.18-2.75) | |
| ≥ 1 | Non-null | 29/117 | 0.65 (0.39-1.09) | 75/114 | 1.62 (1.06-2.48) | |
| ≥ 1 | Null | 24/107 | 0.59 (0.34-1.01) | 46/103 | 1.06 (0.66-1.69) | |
| CYP1A1*2C | GSTM1 + GSTT1 | 0.22 | ||||
| 02 | 04 | 29/71 | 1.00 (referent) | 45/85 | 1.26 (0.71-2.23) | |
| 0 | 1 | 49/159 | 0.73 (0.42-1.26) | 84/144 | 1.41 (0.84-2.37) | |
| 0 | 2 (both null) | 28/99 | 0.69 (0.38-1.28) | 46/53 | 2.03 (1.12-3.69) | |
| ≥ 1 | 0 | 10/63 | 0.39 (0.17-0.87) | 34/54 | 1.46 (0.79-2.72) | |
| ≥ 1 | 1 | 31/105 | 0.75 (0.41-1.36) | 58/104 | 1.31 (0.76-2.26) | |
| ≥ 1 | 2 (both null) | 12/56 | 0.53 (0.25-1.15) | 29/59 | 1.09 (0.58-2.05) | |
| CYP1A1*2C | NQO1 C609T | 0.34 | ||||
| 02 | CC | 34/127 | 1.00 (referent) | 68/93 | 2.64 (1.60-4.36) | |
| 0 | CT + TT | 72/202 | 1.33 (0.83-2.12) | 107/189 | 2.10 (1.33-3.31) | |
| ≥ 1 | CC | 18/94 | 0.75 (0.39-1.41) | 41/98 | 1.41 (0.83-2.41) | |
| ≥ 1 | CT + TT | 35/130 | 1.03 (0.60-1.77) | 80/119 | 2.47 (1.53-4.00) | |
1Number of cases/controls;
2
Adjusted for age, hospital, rank in the Self-Defense Forces, body mass index, cigarette smoking, alcohol use, leisure-time physical activity and parental history of colorectal cancer;
3
Number of variant alleles;
4
Number of null genotypes.