Table 3.
Ratios and 95% confidence intervals (CIs) of inhibition by surinabant (5, 20 and 60 mg) on THC-induced effects, measured from the third THC inhalation until 3 h after the fourth inhalation
| PD assessment | Surinabant dose (mg) | % Inhibition (estimate) | 95% CI |
|---|---|---|---|
| Body sway | 5 | 13.6 | (−32.6, 59.7) |
| 20 | 93.1 | (31.9, 154.3) | |
| 60 | 91.1 | (30.3, 151.8) | |
| VAS alertness | 5 | −8.9 | (−54.9, 37.0) |
| 20 | 72.5 | (18.3, 126.7) | |
| 60 | 82.5 | (25.7, 139.4) | |
| VAS feeling high | 5 | 10.0 | (−20.9, 40.9) |
| 20 | 68.0 | (31.6, 104.4) | |
| 60 | 70.0 | (33.2, 106.9) | |
| VAS external perception | 5 | 17.1 | (−18.3, 52.6) |
| 20 | 88.7 | (43.2, 134.3) | |
| 60 | 89.0 | (43.3, 134.7) | |
| VAS internal perception | 5 | 37.9 | (−5.1, 80.9) |
| 20 | 89.9 | (37.0, 142.8) | |
| 60 | 91.6 | (38.3, 145.0) | |
| Heart rate | 5 | 17.6 | (−13.0, 48.1) |
| 20 | 75.4 | (38.4, 112.3) | |
| 60 | 68.3 | (32.5, 104.2) |