Table 3.

Parametric analysis for the comparison of phosphorylated heat shock protein 27 (pHSP27) and high-sensitivity C-reactive protein (hsCRP) levels between postdose and baseline (i.e. ratio of postdose/baseline)

Parameter	Formulation	Time	Point estimate (95% confidence interval)	P Value
pHSP27	IV	30 min	0.56 (0.50, 0.62)	<0.0001
	IV	60 min	0.56 (0.51, 0.63)	<0.0001
	IV	2 h	0.65 (0.59, 0.73)	<0.0001
	IV	4 h	0.70 (0.63, 0.78)	<0.0001
	IV	6 h	0.84 (0.76, 0.94)	0.0022
	IV	8 h	0.89 (0.80, 0.99)	0.0366
	PO	30 min	0.96 (0.87, 1.07)	0.5081
	PO	60 min	0.67 (0.69, 0.74)	<0.0001
	PO	2 h	0.55 (0.49, 0.61)	<0.0001
	PO	4 h	0.45 (0.41, 0.50)	<0.0001
	PO	6 h	0.51 (0.46, 0.57)	<0.0001
	PO	8 h	0.54 (0.48, 0.60)	<0.0001
hsCRP	IV	6 h	1.00 (0.91, 1,11)	0.9257
	IV	12 h	1.01 (0.92, 1.12)	0.7888
	IV	24 h	0.95 (0.87,1.05)	0.3393
	PO	6 h	0.98 (0.89, 1.08)	0.7396
	PO	12 h	0.95 (0.86, 1.05)	0.3072
	PO	24 h	0.83 (0.76, 0.91)	0.0004