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TPMT activities for 1131 children during thiopurine maintenance chemotherapy (median 13.8 units, range 0–26). Thiopurine genotype was available for 1117 children (1009 wild-type, 87 TPMT*1/*3A, 15 TPMT*1/*3C, four TPMT*1/*2 and two TPMT deficient children TPMT*3A/*3A, TPMT*2/*3A). At the 10.5 unit break point (dotted line) the sensitivity for the TPMT*3 variant allele was 92% (specificity for wild-type 93%). Solid line = median TPMT activities
