Table 3.

Percentage of patients with minimal concentrations below, above or within the therapeutic interval (3–8 mg l⁻¹) following EMA dosing recommendations, WHO dosing recommendations or simulations of the present study

Weight band	Recommendation	<3 mg l−1 (%)	In the range (%)	>8 mg l−1 (%)
3–6 kg	EMA, 7 mg kg−1 BID	57	42	1
	WHO, 50 mg BID	19	73	8
	Simulation, 75 mg BID	4	62	34
6–10 kg	EMA, 7 mg kg−1 BID	27	70	3
	WHO, 75 mg BID	11	71	18
	Simulation, 100 mg BID	3	64	33

Abbreviations are as follows: BID, twice daily; EMA, European Medicines Agency; and WHO, World Health Organization.