Table 2.

Temporal Changes in Echocardiographic Parameters During Treatment by Anthracyclines, Taxanes, and Trastuzumab

	Before Treatment	Postanthracyclines (3 Mo)	6 Mo	9 Mo	12 Mo	End of Treatment
LVEF, %	64 ± 5	62 ± 5*	59 ± 5†	58 ± 5†	58 ± 6†	59 ± 6†
Longitudinal strain, %	21 ± 2	19 ± 2†	18 ± 3†	18 ± 3†	19 ± 2†	19 ± 2†
Radial strain, %	53 ± 15	50 ± 17*	43 ± 16‡	37 ± 16‡	34 ± 16†	41 ± 17‡
Circumferential strain, %	18 ± 4	16 ± 4‡	15 ± 3‡	15 ± 3‡	15 ± 3‡	16 ± 3§

LVEF indicates left ventricular ejection fraction.

The analysis was performed using an ANOVA for repeated measurements on 69 patients with complete follow-up.

^*P<0.03;

^†P<0.0001;

^‡P<0.005;

^§P<0.001 vs before treatment.