Table 1.
Common types of hemoglobinopathies in various parts of Iran.
| Area | α-Chain variants | β-Chain variants | α-Thalassemia | β-Thalassemia |
|---|---|---|---|---|
| Northern Iran | ||||
| Gilan | −α 3.7 kb (42.5%) | IVS II-1 G : A (52.4%) | ||
| Mazandaran | −α 3.7 kb (44.9%) | IVS II-1 G : A (62.1%) | ||
| Golestan | IVS II-1 G : A (33.3%) | |||
| Northwestern Iran | ||||
| East Azerbaijan and Ardabil | IVS II-1 G : A (21%) | |||
| West Azerbaijan | IVS II-1 G : A (35%) | |||
| Northeastern Iran | ||||
| Khorasan | CD 8/9 +G (62.5%) | |||
| Central Iran | ||||
| Isfahan | Hb S | IVS II-1 G : A (20.5 and 28%) | ||
| Southwestern Iran | ||||
| Fars | Hb S | α 3.7 kb (71.7%) | IVS II-1 G : A (24, 31 and 47.8%) | |
| Khuzestan | Hb S Hb D-Punjab |
−α 3.7 kb (62.6%) | CD 36/37 –T (20.5%) IVS II-1 G : A (20%) |
|
| Western Iran | ||||
| Kermanshah |
Hb Q-Iran Hb Setif |
Hb D-Punjab |
IVS II-1 G : A (33%) |
|
| Kurdistan | IVS II-1 G : A (35%) | |||
| Lorestan | CD 36/37 –T (33.8%) IVS II-1 G : A (27.7%) |
|||
| Southern Iran | ||||
| Hormozgan | −α 3.7 kb (79.1%) | IVS I-5 G : C (69%) | ||
| Southeastern Iran | ||||
| Sistan-Balouchestan | IVS I-5 G : C (87.2%) | |||
| Kerman | −α 3.7 kb (83.8%) | IVS I-5 G : C (66.2%) | ||
| Iranians (with different ethnicity) | −α 3.7 kb (60.2%) | IVS II-1 G : A (34%) |