Table 2.
Acute stroke: plasminogen activators
| Studya | Agent | Patients (n) | Δ(T-0)b (h) | Recanalization (%) | Hemorrhage (%) |
|---|---|---|---|---|---|
| Carotid territory: intra-arterial delivery | |||||
| del Zoppo et al185 | SK/u-PA | 20 | 1–24 | 90.0 | 20.0 |
| Mori et al184 | u-PA | 22 | 0.82–7 | 45.5 | 18.2 |
| Matsumoto and Satoh186 | u-PA | 40 | 1–24 | 60.0 | 32.5 |
| PROACT6 | scu-PA/h | 26 | <6.0 | 57.7 | 42.3 |
| C/h | 14 | <6.0 | 14.3 | 7.1 | |
| PROACT-2224 | scu-PA/h | 121 | <6.0 | 65.7 | 10.2 |
| —/h (iv) | 59 | <6.0 | 18.0 | 1.9 | |
| Carotid territory: intravenous delivery | |||||
| Yamaguchi188 | rt-PA | 52 | <6.0 | 38.5 | 28.6 |
| Von Kummer et al189 | rt-PA | 22 | <6.0 | 59.1 | 36.4 |
| del Zoppo et al8 | rt-PA | 93 (104)c | <8.0 | 34.4 | 30.8 |
| Mori et al187 | rt-PA | 19 | <6.0 | 47.4 | 52.6 |
| C | 12 | 16.7 | 41.7 | ||
| Yamaguchi205 | rt-PA | 47 (51)c | <6.0 | 21.3 | 47.1 |
| C | 46 (47)c | 4.4 | 46.8 | ||
Abbreviations: C, control; h, heparin; PROACT, Pro-urokinase in Acute Cerebral Thromboembolism; rt-PA, recombinant tissue-type plasminogen activator; scu-PA, single-chain urokinase plasminogen activator; SK, streptokinase.
a
Studies employing angiography.
b
Time from symptom onset to treatment.
c
Values within parentheses refer to the total number of patients treated in intention-to-treat group.