Signaling events regulated by oxidative stress contribute to the pathogenesis of ROP: Avascular retina and Vasoproliferation. (PLA2, phospholipase A2; COX, cyclooxygenase; PPARγ, peroxisome proliferator-activated receptor gamma; PGS, prostaglandins; PC, prostacyclin; TA, thromboxanes; STAT3, signaling transducer and activator of transcription 3)