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. Author manuscript; available in PMC: 2013 Jul 7.
Published in final edited form as: Pharm Res. 2011 Apr 13;28(8):2034–2044. doi: 10.1007/s11095-011-0429-2

Figure 5.

Figure 5

Effects of PXR inhibition on the induction of CYP2B6 by CPA and IFO. Human primary hepatocytes from donors (HL-20 and HL-25) were treated for 24 hr with CITCO (1 μM), RIF (10 μM), SFN (25 μM), CPA (1 mM), and IFO (1 mM), and cotreatment of SFN (25 μM) with CITCO, RIF, CPA, and IFO, respectively. The expression of CYP2B6 mRNA was assessed in real-time RT-PCR assays (Materials and Methods). All data are expressed as mean ± SD (n=3). **: p < 0.01.