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Histologic features of head and neck squamous cell carcinoma (HNSCC). The prototypic HNSCC is characterized by nests of squamous cells with pink cytoplasm, intercellular bridges and keratin pearl formation set in a background of stromal fibrosis (a). Subtypes of HNSCC include the basaloid variant (b), the spindle-cell variant (c), and the papillary variant (d ).
