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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Clin Nutr. 2013 Feb 19;32(5):819–823. doi: 10.1016/j.clnu.2013.02.006

Table.3.

Odds ratio of heart failure according to plasma phospholipid saturated fatty acids in the Physicians’ Health Study

Odds ratio for heart failure

Cases Model 1* Model 2 Model 3

OR (95% CI) P value OR (95% CI) P value OR (99.17% CI) P value
14:0 Q1 199 1 Ref 1 Ref 1 Ref
14:0 Q2 194 0.99(0.75, 1.30) 0.923 0.97(0.72, 1.31) 0.838 0.96(0.64, 1.46) 0.816
14:0 Q3 184 0.93(0.71, 1.23) 0.624 0.80(0.59, 1.09) 0.153 0.79(0.52, 1.22) 0.159
14:0 Q4 211 1.08(0.81, 1.44) 0.581 1.09(0.80, 1.49) 0.588 1.03(0.65, 1.64) 0.854
Per SD higher 14:0 1.03(0.93, 1.14) 0.572 1.03(0.92, 1.15) 0.585 1.02(0.86, 1.20) 0.719
15:0 Q1 218 1 Ref 1 Ref 1 Ref
15:0 Q2 187 0.88(0.66, 1.16) 0.359 0.76(0.56, 1.04) 0.083 0.78(0.50, 1.20) 0.122
15:0 Q3 217 1.00(0.76, 1.32) 0.996 0.89(0.65, 1.22) 0.482 0.95(0.61, 1.48) 0.415
15:0 Q4 166 0.77(0.57, 1.05) 0.096 0.71(0.50, 1.01) 0.055 0.73(0.44, 1.12) 0.101
Per SD higher 15:0 0.92(0.83, 1.03) 0.147 0.91(0.80, 1.02) 0.119 0.91(0.76, 1.07) 0.156
16:0 Q1 172 1 Ref 1 Ref 1 Ref
16:0 Q2 187 1.11(0.82, 1.49) 0.498 1.03(0.75, 1.42) 0.844 1.12(0.71, 1.77) 0.521
16:0 Q3 183 1.10(0.82, 1.48) 0.522 0.99(0.71, 1.39) 0.966 1.11(0.68, 1.81) 0.742
16:0 Q4 246 1.49(1.11, 2.00) 0.009 1.49(1.06, 2.09) 0.023 1.68(0.98, 2.87) 0.011
P for trend 0.01 0.02 0.01
Per SD higher 16:0 1.15(1.03, 1.28) 0.010 1.14(1.01, 1.29) 0.042 1.20(0.99, 1.45) 0.014
18:0 Q1 185 1 Ref 1 Ref 1 Ref
18:0 Q2 186 1.02(0.76, 1.37) 0.890 0.92(0.67, 1.26) 0.581 1.01(0.64, 1.57) 0.979
18:0 Q3 185 1.01(0.75, 1.37) 0.925 0.86(0.62, 1.20) 0.374 1.02(0.63, 1.66) 0.901
18:0 Q4 232 1.28(0.95, 1.72) 0.101 1.04(0.75, 1.44) 0.816 1.28(0.78, 2.11) 0.189
Per SD higher 18:0 1.11(1.00, 1.23) 0.056 1.03(0.92, 1.16) 0.601 1.12(0.93, 1.35) 0.105
20:0 Q1 204 1 Ref 1 Ref 1 Ref
20:0 Q2 200 0.96(0.70, 1.31) 0.777 0.94(0.67, 1.33) 0.732 0.91(0.57, 1.48) 0.621
20:0 Q3 212 1.00(0.66, 1.50) 0.992 0.95(0.62, 1.48) 0.830 1.02(0.55, 1.88) 0.946
20:0 Q4 172 0.76(0.50, 1.17) 0.218 0.72(0.46, 1.15) 0.169 0.81(0.41, 1.59) 0.399
Per SD higher 20:0 0.94(0.80, 1.10) 0.430 0.89(0.75, 1.06) 0.334 0.93(0.71, 1.23) 0.773
22:0 Q1 215 1 Ref 1 Ref 1 Ref
22:0 Q2 191 0.85(0.62, 1.15) 0.291 0.87(0.62, 1.21) 0.409 0.91(0.57, 1.46) 0.314
22:0 Q3 194 0.85(0.61, 1.17) 0.314 0.78(0.55, 1.11) 0.170 0.82(0.48, 1.38) 0.305
22:0 Q4 188 0.80(0.56, 1.14) 0.223 0.74(0.50, 1.09) 0.126 0.86(0.46, 1.56) 0.503
Per SD higher 22:0 0.93(0.82, 1.06) 0.279 0.89(0.77, 1.03) 0.118 0.93(0.74, 1.16) 0.366
*

Conditional logistic regression matched for matching factors age, race, year of birth, the date of blood kid returned,

Adjusted for matching factors and body mass index, smoking status, exercise level, alcohol consumption, history of diabetes, and history of atrial fibrillation.

Adjusted for matching factors and covariates in model 2 plus all of saturated fatty acids.

alpha=0.0083 (0.05/6) and 99.17% CI were used to construct individual confidence intervals to achieve an overall 95% confidence intervals using Bonferroni correction.

HHS Vulnerability Disclosure