Table.3.
Odds ratio of heart failure according to plasma phospholipid saturated fatty acids in the Physicians’ Health Study
Odds ratio for heart failure | |||||||
---|---|---|---|---|---|---|---|
Cases | Model 1* | Model 2† | Model 3‡ | ||||
OR (95% CI) | P value | OR (95% CI) | P value | OR (99.17% CI) | P value | ||
14:0 Q1 | 199 | 1 | Ref | 1 | Ref | 1 | Ref |
14:0 Q2 | 194 | 0.99(0.75, 1.30) | 0.923 | 0.97(0.72, 1.31) | 0.838 | 0.96(0.64, 1.46) | 0.816 |
14:0 Q3 | 184 | 0.93(0.71, 1.23) | 0.624 | 0.80(0.59, 1.09) | 0.153 | 0.79(0.52, 1.22) | 0.159 |
14:0 Q4 | 211 | 1.08(0.81, 1.44) | 0.581 | 1.09(0.80, 1.49) | 0.588 | 1.03(0.65, 1.64) | 0.854 |
Per SD higher 14:0 | 1.03(0.93, 1.14) | 0.572 | 1.03(0.92, 1.15) | 0.585 | 1.02(0.86, 1.20) | 0.719 | |
15:0 Q1 | 218 | 1 | Ref | 1 | Ref | 1 | Ref |
15:0 Q2 | 187 | 0.88(0.66, 1.16) | 0.359 | 0.76(0.56, 1.04) | 0.083 | 0.78(0.50, 1.20) | 0.122 |
15:0 Q3 | 217 | 1.00(0.76, 1.32) | 0.996 | 0.89(0.65, 1.22) | 0.482 | 0.95(0.61, 1.48) | 0.415 |
15:0 Q4 | 166 | 0.77(0.57, 1.05) | 0.096 | 0.71(0.50, 1.01) | 0.055 | 0.73(0.44, 1.12) | 0.101 |
Per SD higher 15:0 | 0.92(0.83, 1.03) | 0.147 | 0.91(0.80, 1.02) | 0.119 | 0.91(0.76, 1.07) | 0.156 | |
16:0 Q1 | 172 | 1 | Ref | 1 | Ref | 1 | Ref |
16:0 Q2 | 187 | 1.11(0.82, 1.49) | 0.498 | 1.03(0.75, 1.42) | 0.844 | 1.12(0.71, 1.77) | 0.521 |
16:0 Q3 | 183 | 1.10(0.82, 1.48) | 0.522 | 0.99(0.71, 1.39) | 0.966 | 1.11(0.68, 1.81) | 0.742 |
16:0 Q4 | 246 | 1.49(1.11, 2.00) | 0.009 | 1.49(1.06, 2.09) | 0.023 | 1.68(0.98, 2.87) | 0.011 |
P for trend | 0.01 | 0.02 | 0.01 | ||||
Per SD higher 16:0 | 1.15(1.03, 1.28) | 0.010 | 1.14(1.01, 1.29) | 0.042 | 1.20(0.99, 1.45) | 0.014 | |
18:0 Q1 | 185 | 1 | Ref | 1 | Ref | 1 | Ref |
18:0 Q2 | 186 | 1.02(0.76, 1.37) | 0.890 | 0.92(0.67, 1.26) | 0.581 | 1.01(0.64, 1.57) | 0.979 |
18:0 Q3 | 185 | 1.01(0.75, 1.37) | 0.925 | 0.86(0.62, 1.20) | 0.374 | 1.02(0.63, 1.66) | 0.901 |
18:0 Q4 | 232 | 1.28(0.95, 1.72) | 0.101 | 1.04(0.75, 1.44) | 0.816 | 1.28(0.78, 2.11) | 0.189 |
Per SD higher 18:0 | 1.11(1.00, 1.23) | 0.056 | 1.03(0.92, 1.16) | 0.601 | 1.12(0.93, 1.35) | 0.105 | |
20:0 Q1 | 204 | 1 | Ref | 1 | Ref | 1 | Ref |
20:0 Q2 | 200 | 0.96(0.70, 1.31) | 0.777 | 0.94(0.67, 1.33) | 0.732 | 0.91(0.57, 1.48) | 0.621 |
20:0 Q3 | 212 | 1.00(0.66, 1.50) | 0.992 | 0.95(0.62, 1.48) | 0.830 | 1.02(0.55, 1.88) | 0.946 |
20:0 Q4 | 172 | 0.76(0.50, 1.17) | 0.218 | 0.72(0.46, 1.15) | 0.169 | 0.81(0.41, 1.59) | 0.399 |
Per SD higher 20:0 | 0.94(0.80, 1.10) | 0.430 | 0.89(0.75, 1.06) | 0.334 | 0.93(0.71, 1.23) | 0.773 | |
22:0 Q1 | 215 | 1 | Ref | 1 | Ref | 1 | Ref |
22:0 Q2 | 191 | 0.85(0.62, 1.15) | 0.291 | 0.87(0.62, 1.21) | 0.409 | 0.91(0.57, 1.46) | 0.314 |
22:0 Q3 | 194 | 0.85(0.61, 1.17) | 0.314 | 0.78(0.55, 1.11) | 0.170 | 0.82(0.48, 1.38) | 0.305 |
22:0 Q4 | 188 | 0.80(0.56, 1.14) | 0.223 | 0.74(0.50, 1.09) | 0.126 | 0.86(0.46, 1.56) | 0.503 |
Per SD higher 22:0 | 0.93(0.82, 1.06) | 0.279 | 0.89(0.77, 1.03) | 0.118 | 0.93(0.74, 1.16) | 0.366 |
Conditional logistic regression matched for matching factors age, race, year of birth, the date of blood kid returned,
Adjusted for matching factors and body mass index, smoking status, exercise level, alcohol consumption, history of diabetes, and history of atrial fibrillation.
Adjusted for matching factors and covariates in model 2 plus all of saturated fatty acids.
alpha=0.0083 (0.05/6) and 99.17% CI were used to construct individual confidence intervals to achieve an overall 95% confidence intervals using Bonferroni correction.