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. 2013 Jul 8;3:28. doi: 10.3389/fcimb.2013.00028

Figure 1.

Figure 1

Identification of BtpB. (A) Identification of BtpB as bacterial member of TLR/IL-1R (TIR) family. Comparison of the predicted amino acid sequences of the TIR domain of BtpB with BtpA and the human members of the TIR family: MAL, MyD88, TLR2 and TLR4. The alignment was constructed with T-Coffee::advanced server from EMBnet (http://www.ch.embnet.org) and coloring scheme corresponds to standard ClustalX in which each residue in the alignment is assigned a color if the amino acid profile at each position meets a minimum criteria specific for the residue type. Box 1 corresponds to the signature sequence of the TLR family. (B) Alignment of BtpB amino acid sequences for B. abortus 2308 (BAB1_0756), B. suis 1330 (BR0735), B. abortus 9-941 (BruAb1_0752) and B. melitensis 16M (BME1216). The annotated starting codons (Methionine/Valine) are highlighted in red. Amino acid differences are shaded in red.