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Metabolism of ethanol into acetaldehyde by three enzymatic systems. In the liver alcohol dehydrogenase (ADH) plays a major role, while catalase and cytochrome P450 (CYP2E1) play minor roles. In the brain, ADH (ADH1) is not expressed, but catalase mainly, and CYP2E1 to a minor extent, metabolize ethanol into acetaldehyde. Aldehyde dehydrogenase-2 (ALDH2) is present in virtually all cells (Drawn from Zimatkin et al., 2006).
