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. 2013 Jul;183(1):119–130. doi: 10.1016/j.ajpath.2013.03.025

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© 2013 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.

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Infusion of Ang II in rat isolated perfused kidneys affects glomerular barrier function and integrity. A: Proteinuria levels at baseline (white bars) and after a 10-minute infusion with 16 ng/minute Ang II or vehicle (grey bars). ^∗P < 0.01 versus baseline. B: Representative images of nephrin immunofluorescence (red) in glomeruli of rats after Ang II (left panel) or vehicle (right panel) infusion. C: Transmission electron micrographs of the capillary wall ultrastructure of rats infused with Ang II (left panel) or vehicle (right panel). Arrowhead, podocyte effacement; arrows, podocyte slits with or without the linear diaphragm between neighboring podocytes.