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. 2013 Jul 8;4:83. doi: 10.3389/fendo.2013.00083

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Copyright © 2013 Larco, Semsarzadeh, Cho-Clark, Mani and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Gonadotropin-releasing hormone neuronal migratory route during development. (A) GnRH neurons are born in the nasal placode near the vomeronasal organ (VMO) at approximately embryonic day (ED) 11.5 in the mouse. As development progresses GnRH neurons begin to enter the CNS (dashed lines) at ED12.5 and begin to descend within the basal forebrain region at ED15.5. (B) Most GnRH neurons are within the CNS at ED15.5 however the remaining GnRH neurons in the nasal septum (NS) have a morphologically distinct migratory pattern relative to neurons found near the telencephalon (tel). Arrow indicates descending GnRH neurons of a mouse ED15.5 brain (Wu, TJ unpublished data). LTV, left telencephalic vesicle; OB, olfactory bulb; OE, olfactory epithelium; PIT, pituitary; MV, mesencephalic vesicle; T, tectum.