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. 2013 Jul 8;3:2157. doi: 10.1038/srep02157

Figure 2. Recovery of motor function in drug-naive behavior tests over the 12-week follow up after AAV treatment.

Figure 2

Due to the ease in longitudinal assessments, the corridor test (A) was administered at several time points, which revealed an early partial recovery in the TH-GCH1:1E11 group at 1 week, a transient overcompensation (strong contralateral bias) at 3 weeks and a stable response with slight bias in left retrievals at 5 weeks and onwards. Animals in the TH-GCH1:1E10 group displayed a similar behavior, however, at a slower rate and without the overcompensation at 3 weeks post-AAV. The TH-GCH1:5E9 group showed only partial recovery but were significantly different from Les-Sham at the 12 week time point. Animals receiving the TH-GCH1:9E8 and GCH1-GCH1:2E11 did not show any recovery compared with Les-Sham. Behavioral recovery in the stepping (B) and cylinder (C) tests were comparable in the 1E11 and 1E10 groups, while the response in the 5E9 group was less pronounced or not detectable, respectively. Statistics: Repeated measures ANOVA (A) Time F(3,20) = 65.85 p < 0.001; Time × Group F(3,20) = 16.64 p < 0.001; (B) Time F(2,9) = 129.05 p < 0.001; Time × Group F(2,9) = 39.26 p < 0.001; (C) Time F(2,12) = 73.82 p < 0.001; Time × Group F(2,12) = 43.86 p < 0.001; One-way ANOVA at each time point followed by post hoc comparison with Tukey's HSD when Levene's test was significant (p < 0.05) otherwise by Dunnett's T3 test. * = different from Les-Sham p < 0.05, # = different from intact controls p < 0.05. Error bars represent mean SEM.