Table 1. Single-agent trials of IFNα: a historical overview.

Trial	IFNα dose	IFNα form	n	CHR rate (%)	Median survival (months)
Talpaz et al.6	9 MU	Partially pure	7	71
Talpaz et al.7	3–9 MU	Partially pure	51	71
Alimena et al.11a	2–5 MU/m2	rIFNα-2b	105	59
Talpaz et al.8	3–9 MU (partially pure) or 5 MU/m2 (rIFNα-2a)	Partially pure or rIFNα-2a	96	73	62
Niederle et al.13	4 MU/m2 IFNα	rIFNα-2b	48	46
Ozer et al.10	5 MU/m2	rIFNα-2b	107	22	66
Thaler et al.12	3.5 MU	rIFNα-2c	80	39
Hehlmann et al.15	5 MU/m2	rIFNα-2a or rIFNα-2b	133	31	66
Italian Cooperative Study Group on Chronic Myeloid Leukemia14	3–9 MU	rIFNα-2a	218	45 (complete and partial)	72
Allan et al.17	3–12 MU	Highly purified	293	68	61
Ohnishi et al.16	3–9 MU	rIFNα-2a	80	39

Abbreviations: CHR, complete hematological remission; rIFNα, recombinant interferon-α.