TABLE 3.
Toxicities observed for patients by cohort
| Toxicity | 200 mg/M2
|
250 mg/M2
|
||||||
|---|---|---|---|---|---|---|---|---|
| Grade 1 or 2
|
Grade 3+
|
Grade 1 or 2
|
Grade 3+
|
|||||
| N | % | N | % | N | % | N | % | |
| Leukocytes | 4 | 33 | 0 | 0 | 2 | 67 | 1 | 33 |
| Platelets | 6 | 50 | 1 | 8 | 0 | 0 | 2 | 67 |
| Hemoglobin | 2 | 17 | 2 | 17 | 0 | 0 | 2 | 67 |
| Nausea | 3 | 25 | 0 | 0 | 2 | 67 | 0 | 0 |
| Vomiting | 0 | 0 | 0 | 0 | 1 | 33 | 0 | 0 |
| Diarrhea | 1 | 8 | 0 | 0 | 2 | 67 | 0 | 0 |
| Alkaline phosphatase | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Neuropathy: sensory | 0 | 0 | 0 | 0 | 1 | 33 | 0 | 0 |
| Neutrophils/granulocytes | 1 | 8 | 0 | 0 | 0 | 0 | 2 | 67 |
| Calcium, serum-low | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Bilirubin | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| AST, SGOT | 0 | 0 | 1 | 8 | 0 | 0 | 0 | 0 |
| Pain: abdomen NOS | 0 | 0 | 1 | 8 | 0 | 0 | 0 | 0 |
| Acidosis | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 33 |
| Partial thromboplastin time | 1 | 8 | 0 | 0 | 0 | 0 | 0 | 0 |
| Liver dysfunction | 0 | 0 | 0 | 0 | 1 | 33 | 0 | 0 |
| Ileus, GI | 1 | 8 | 0 | 0 | 0 | 0 | 1 | 33 |
| Lymphopenia | 3 | 25 | 9 | 75 | 0 | 0 | 3 | 100 |
| Malabsorption | 0 | 0 | 1 | 8 | 0 | 0 | 1 | 33 |
| Infection with unknown ANC | 0 | 0 | 1 | 8 | 0 | 0 | 0 | 0 |
| Mucositis/stomatitis | 0 | 0 | 0 | 0 | 1 | 33 | 0 | 0 |
| Hemorrhage | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 33 |
| Blood/bone marrow | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 33 |