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. Author manuscript; available in PMC: 2013 Jul 8.
Published in final edited form as: Ann Surg Oncol. 2008 May 21;15(8):2137–2145. doi: 10.1245/s10434-008-9967-1

TABLE 4.

Peritoneal fluid and plasma pharmacokinetics after IPHC with oxaliplatin

200 mg/M2 250 mg/M2 P-value
Peritoneal fluid values
 t1/2 (min) 70.1 ± 23.8 65.3 ± 10.3 0.99
 Cmax (mg/L) 42.0 ± 9.4 51.3 ± 1.1 0.11
 Cmin (mg/L) 14.0 ± 4.3 15.9 ± 2.9 0.44
 AUC (mg/L h) 49.6 ± 8.6 62.7 ± 10.2 0.09
Plasma values
 t1/2 (min) 94.2 ± 64.8 61.2 ± 5.0 0.52
 Cmax (mg/L) 2.2 ± 0.77 3.2 ± 0.6 0.03
 Cmin (mg/L) 0.66 ± 0.4 0.77 ± 0.3 0.72
 AUC (mg/L h) 23.2 ± 11.4 31.1 ± 3.0 0.22

Values are expressed as the mean±standard deviation.

t1/2, half life; Cmax, maximum concentration of drug; Cmin, minimum concentration of drug; AUC, area under the curve.