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The time course of normal maturation detected on T1 (upper row)/T2 (middle row) DTI (FA map, lower row). The maturation (predominantly the myelination pattern) has a profound impact on T1- and T2-weighted imaging. The extent of the contrast change is so large that the gray/white matter contrast inverts in the first 12 months. During this time period, FA remains more stable, especially in the deep brain regions, while the peripheral white matter has a noticeble FA increase
