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AS-IV decreased renal MPO activity and inhibited the activity and mRNA expression of NF-κB in rats with ischemic AKI. Renal MPO activity (a), NF-κB activity (b), and mRNA expression (c) in sham, vehicle-, or AS-IV-pretreated rats at 12 h of reperfusion. Renal MPO activity (d), NF-κB activity (e), and mRNA expression (f) in sham, vehicle-, or AS-IV-pretreated rats at 24 h of reperfusion. Results are expressed as mean ± SD. *P < 0.05 versus Sham group; # P < 0.05 versus Veh group.
