Figure 7.

AS-IV downregulated the mRNA expression of TNF-α, MCP-1, and ICAM-1 in rats with ischemic AKI. Representative real-time PCR of TNF-α (a), MCP-1 (b), and ICAM-1 (c) in renal tissues from sham, vehicle-, or AS-IV-pretreated rats at 12 h of reperfusion. Representative real-time PCR of TNF-α (d), MCP-1 (e), and ICAM-1 (f) in renal tissues from sham, vehicle-, or AS-IV-pretreated rats at 24 h of reperfusion. Results are expressed as mean ± SD. *P < 0.05 versus Sham group; ^# P < 0.05 versus Veh group.