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RNase-L mediates IFNβ production by BMDM in response to bacterial RNA. (A) BMDM were infected with Top10 or LF82 strains of E. coli at an MOI of 5 or 20 for 8 hours and IFNβ was measured by ELISA. (B) BMDMs were transfected with E. coli (Top10) RNA at the indicated times and doses, then IFN production was measured by ELISA. Data represent mean ± SE. *p < 0.05, **p < 0.01, ***p < 0.005.
