Figure 1. Elevated cytosolic Ca²⁺ and enhanced myogenic tone in parenchymal arterioles from SAH animals.

A–C: Representative simultaneous [Ca²⁺]_i and diameter measurements obtained from intact arterioles isolated from unoperated (control; A), sham-operated (sham; B) and SAH (C) animals. Recordings were obtained during step-wise increases in intravascular pressure and subsequent nimodipine application (300 nM) at 60 mmHg. Dashed traces represent diameters in Ca²⁺-free aCSF containing nimodipine (300 nM). D, E. Summary of [Ca²⁺]_i (D) and constriction (E) obtained in the absence and presence of 300 nM nimodipine. *P<0.05, **P<0.01 vs. control unoperated and sham-operated. F. Relationship between [Ca²⁺]_i and constriction for arterioles isolated from control, sham-operated and SAH animals derived from summary data depicted in panel D and E. Reproduced from Nystoriak et al., American Journal of Physiology, 2011 [13].