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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: Acta Neurochir Suppl. 2013;115:173–177. doi: 10.1007/978-3-7091-1192-5_33

Figure 2. Proposed signaling pathway of OxyHb-induced KV current suppression involving HB-EGF and EGFR activation.

Figure 2

Schematic diagram illustrates OxyHb-induced KV current suppression via enhanced MMP activation and HB-EGF shedding. Abbreviations: OxyHb: oxyhemoglobin, MMP: matrix metalloprotease, ADAM: a disintegrin and metalloprotease, HB-EGF: heparin binding epidermal growth factor like growth factor, EGFR: epidermal growth factor receptor, PY: phosphorylated tyrosine residue, KV channel: voltage-dependent potassium channel. Reproduced from Koide et al., American Journal of Physiolgy, 2007 [9].