Fig. 1.

Murine norovirus genome organization. The murine norovirus genome is shown organized into three different open reading frames, together with the 5′- and 3′-nontranslated regions (NTR). The murine norovirus PPMO targets are indicated in the figure (PMOs were synthesized as PPMOs). The direction of the arrow indicates the sense of the PPMO. Not shown is ORF4, which partially overlaps ORF2 (Thackray et al., 2007).