Fig. 7.
Protein translation inhibition by Noro 1.1 PPMO measured by a luciferase reporter assay. The inhibitory activity of Noro 1.1 against several targets (indicated in the graph) containing sequence variations is shown. Only targets that resulted in some degree of luciferase translation inhibition are plotted compared to the bovine strain which represents no inhibition of luciferase activity. These dose–response curves are representative of at least 2 independent repetitions of the protein translation inhibition experiment for each target, carried out by different investigators in independent laboratories.