Fig. 7.

XIAP accumulates in LVS-infected PMNs. PMNs were left untreated or infected with LVS for the indicated amount of time, and immunoblots of cell lysates were probed to detect XIAP. Full-length XIAP disappears in parallel with accumulation of a p30 XIAP fragment in PMNs undergoing constitutive apoptosis. By contrast, XIAP is maintained at high levels in LVS-infected PMNs over 48 h, and only minimal amounts of the p30 fragment were detected. The data shown are representative of three independent experiments.