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. Author manuscript; available in PMC: 2013 Jul 8.
Published in final edited form as: Nat Struct Mol Biol. 2010 May 23;17(6):659–665. doi: 10.1038/nsmb.1844

Figure 5.

Figure 5

Model for activation of the WAVE complex. The WAVE complex is intrinsically inactive. The first step in activation is phosphorylation, which primes the complex for interaction with the membrane. Binding to acidic phospholipids, particularly PIP3 and Rac-GTP, is required for activation. Figure is modified from previous work102.