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. Author manuscript; available in PMC: 2013 Jul 8.
Published in final edited form as: Clin Cancer Res. 2011 Feb 7;17(8):2512–2520. doi: 10.1158/1078-0432.CCR-10-2736

Table 1.

Single-dose unbound and total GDC-0449 PK parameters from patients enrolled in stage 1

Stage 1 patients
by dose cohort		 Mean ± SD
Unbound GDC-0449
 Total GDC-0449
Tmax, d Cmax, μmol/L AUClast, μmol/L h Tmax, d Cmax, μmol/L AUClast, μmol/L h
150 mg (n = 7) 2.43 ± 2.22 0.0093 ± 0.0121 0.577 ± 0.769 2.43 ± 2.22 3.58 ± 1.34 322 ± 185
270 mg (n = 9) 1.61 ± 1.16 0.0324 ± 0.0247 2.41 ± 1.37 2.11 ± 0.928 6.34 ± 3.40 839 ± 458
540 mg (n = 4) 0.834 ± 0.871 0.0292 ± 0.0289 2.43 ± 1.45 2.04 ± 1.34 6.81 ± 2.69 1,010 ± 446