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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nutr Rev. 2013 May 15;71(7):441–457. doi: 10.1111/nure.12030

Fig. 3. Dietary phytochemicals impacting three epigenetic codes.

Fig. 3

Schematic view showing possible effects of epigenetic changes of gene silencing during carcinogenesis. Epigenetic processes are important in regulating gene activity and are susceptible to epigenetic dysregulation by environmental toxicants. This dysregulation involves the aberrant methylation of CpG sites which in turn recruits CpG binding protein (methyl binding protein) and HDACs and changes the chromatin structure. miRNA interference leads to inhibition of mRNA translation. Strategies to reverse the epigenetic changes by the combination of dietary components, could be a chemopreventive approach to control tumorigenesis.