Fig. 1.

IKKε is critically involved in kGPCR-induced tumorigenesis. (A) Ikbke^+/− and Ikbke^−/− MEFs infected with control lentivirus (Vector) or lentivirus expressing kGPCR were mixed with SVEC cells and injected into nude mice s.c. Tumor weight was determined when mice were killed. (B–F) TIE2-tva mice were injected with RCAS-kGPCR and tumors on the tail were photographed (B). (C) H&E staining and immunohistochemical staining of the fixed tumor sections. Numbers indicate the percentage of kGPCR+ and IKKε+ cells. (D) Three staining patterns (indicated by red arrows) of IKKε in tumor tissues in C. Human KS tumors were stained for latent nuclear antigen LANA (E) and IKKε (F).