Table 1.

Summary of parameters and outcomes of the PET/fMRI paradigm for putamen in two animals (M1 and M2)

Study parameters and outcomes	Dose 1		Dose 2		Dose 3		Dose 4
Study parameters*
Injected RAC mass, μg/kg	0.3	0.3	4.5	4.5	16	16	40	40
Specific activity, μCi/nmol	1,350	1,350	53	53	8.9	8.9	6	6
Study outcomes	M1	M2	M1	M2	M1	M2	M1	M2
BPND	3.0	5.6	1.8	3.2	1.1	1.6	0.3	0.9
	3.3	5.1	1.6	2.4	0.8	1.1	0.2	0.6
RAC occupancies† , %	0	0	40	43	63	71	90	84
Peak RAC occupancies† , %	0	0	50	52	74	77	94	88
Peak CBV, %	0.5‡ ± 0.3	−1.1‡ ± 0.4	2.2	5.8	5.6	10	7.3	12

^*Average values from studies in two animals.

^†Occupancies are computed relative to dose 1.

^‡Average CBV from repeated studies.