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. 2013 Jun 19;110(27):10888–10889. doi: 10.1073/pnas.1309471110

Fig. 1.

Fig. 1.

(Left) Schematics for the synaptic neuroransmission in the striatum. GABAergic neurons (MSN) that project to the external globus pallidum express D2R. DA binding to D2R inhibits neuronal activity. Glutametergic and dopaminergic terminals also express D2R, and DA binding to D2R in these terminals inhibits DA and glutamate release, respectively. (Right) Pharmacologic doses of raclopride (RAC) block D2Rs in GABAergic, dopaminergic, and glutamatergic terminals, increasing DA and glutamate release in the basal ganglia with a resultant increase in stimulatory D1R signaling.