Table 1.

List of protein regions that are involved in highly correlated residue motions with cross-correlations >0.6 in the dual-boost aMD simulation of the apo M2 receptor

Region	Residues
	Extracellular	Intracellular
TM3	94–107	115–126
TM4	156–164	138–152
TM5	184–195	197–210
TM6	400–410	385–399
TM7	422–432	436–440
ECL2	163–184	—