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. 2013 Jun 17;110(27):11181–11186. doi: 10.1073/pnas.1221803110

Fig. 3.

Fig. 3.

Oxo-m activates predominantly M3 mAChRs on Purkinje cells. (A) Wash-in of oxo-m caused a moderate depression of EPSC amplitudes in the presence of the M1 receptor antagonist pirenzepine (10 µM; gray bar; n = 7). (B) In contrast, the suppressive effect of oxo-m was prevented in the presence of the M3 receptor antagonist DAU 5884 (1 µM; gray bar; n = 9). (C) Bath application of DAU 5884 (1 µM; gray bar) rescued LTP when oxo-m was present during tetanization (n = 6). (Scale bars: 20 ms, 100 pA.) Error bars indicate SEM.