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Suggested signaling pathway of M1/M3 muscarinic receptors. Activation of M1/M3 receptors on Purkinje cells linked to the activation of PLCβ triggers cannabinoid production and release that is sufficient to block presynaptically expressed LTP. eCBs, endocannabinoids; PIP2, phosphatidylinositol 4,5-bisphosphate; VGCC, voltage-gated calcium channel.
