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AFM of WT and mutant SOD1 fibrils. Insets show the magnified helical twist of the fibrils. WT, L38V, G93A, and G93S have and average pitch length around 55–65 nm. (Scale bar: 100 nm.) Periodicity profile along the fibril axis is shown on the right of each AFM image. (Vertical bar: 0.4 nm.) Distance between two peaks (pitch distance) is marked by the arrows.
