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Helical pitch distances for WT and mutant SOD1 fibrils. Histogram (bin size = 10 nm) of helical pitch distances for WT and mutants with Gaussian fit peak curve (black line). n > 200 counts. WT, L38V, G93A, and G93S have peak centers at 60.9 nm, 50.5 nm, 54.5 nm, and 49.3 nm, respectively. Peak centers for G37R and G41D are left shifted to shorter lengths, 33.9 nm and 33.6 nm. The distribution of helical pitch distances for D101N is more diverse, and the peak centers at 63.3 nm.
