Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Macrophages ignore normal cells as a result of negative interactions in which the CD47–SIRP-α pair promote the “don’t eat me” signal. Cancer cells show high levels of CD47 and avoid phagocytosis despite having a higher level of calreticulin (12) (B), but blocking CD47 with antibody favors their uptake (C).
