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. 2013 Aug 10;19(5):433–447. doi: 10.1089/ars.2012.4563

FIG. 6.

FIG. 6.

Effects of novel synthesized nNOS inhibitors on human melanoma cells. (A) Inhibition of UVA radiation-induced intracellular NO generation detected by Griess reagents. #p<0.05 compared to control; *p<0.05 compared to UVA-treated sample (n=3); (B) Reduced invasion potential of metastatic melanoma. Bars represent the means of invaded cells counted in 20 highlight fields and normalized to control (set as 1.0). *p<0.05 compared to control (n=2). (C) L-arginine-stimulated adhesion of metastatic melanoma A375 cells to fibroblast monolayer were inhibited by nNOS inhibitors. Cells were seeded on top of fibroblast monolayer in the presence of different nNOS inhibitors (2 μM) for 1 h. The data were represented as fold of control. *p<0.05 compared to DMSO+L-arginine treatment (n=3). (D) Cytotoxicity of cpd2 in human melanoma cell lines by MTT assay (n=3).