Table 1.
WHO Clinical Conditions or Symptoms for Adults and Adolescents with Confirmed HIV Infection12
Clinical Stage 1 |
Asymptomatic |
Persistent generalized lymphadenopathy |
Clinical Stage 2 |
Moderate unexplained weight loss (<10% of presumed or measured body weight) |
Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media, and pharyngitis) |
Herpes zoster |
Angular cheilitis |
Recurrent oral ulceration |
Papular pruritic eruptions |
Seborrhoeic dermatitis |
Fungal nail infections |
Clinical Stage 3 |
Unexplained severe weight loss (>10% of presumed or measured body weight) |
Unexplained chronic diarrhea for longer than 1 month |
Unexplained persistent fever (above 37.6°C intermittent or constant, for longer than 1 month) |
Persistent oral candidiasis |
Oral hairy leukoplakia |
Pulmonary tuberculosis (current) |
Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis or bacteremia) |
Acute necrotizing ulcerative stomatitis, gingivitis, or periodontitis |
Unexplained anemia (<8 g/dL), neutropenia (<0.5×109 per liter) or chronic thrombocytopenia (<50×109 per liter) |
Clinical Stage 4 |
HIV wasting syndrome |
Pneumocystis pneumonia |
Recurrent severe bacterial pneumonia |
Chronic herpes simplex infection (orolabial, genital, or anorectal of more than 1 month's duration or visceral at any site) |
Esophageal candidiasis (or candidiasis of trachea, bronchi or lungs) |
Extrapulmonary tuberculosis |
Kaposi's sarcoma |
Cytomegalovirus infection (retinitis or infection of other organs) |
Central nervous system toxoplasmosis |
HIV encephalopathy |
Extrapulmonary cryptococcosis including meningitis |
Disseminated non-tuberculous mycobacterial infection |
Progressive multifocal leukoencephalopathy |
Chronic cryptosporidiosis (with diarrhea) |
Chronic isosporiasis |
Disseminated mycosis (coccidiomycosis or histoplasmosis) |
Recurrent non-typhoidal Salmonella bacteremia |
Lymphoma (cerebral or B-cell non-Hodgkin) or other solid HIV-associated tumors |
Invasive cervical carcinoma |
Atypical disseminated leishmaniasis |
Symptomatic HIV-associated nephropathy or symptomatic HIV-associated cardiomyopathy |