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. 2013 Jul;27(7):392–397. doi: 10.1089/apc.2013.0099

Table 1.

WHO Clinical Conditions or Symptoms for Adults and Adolescents with Confirmed HIV Infection12

Clinical Stage 1
 Asymptomatic
 Persistent generalized lymphadenopathy
Clinical Stage 2
 Moderate unexplained weight loss (<10% of presumed or measured body weight)
 Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media, and pharyngitis)
 Herpes zoster
 Angular cheilitis
 Recurrent oral ulceration
 Papular pruritic eruptions
 Seborrhoeic dermatitis
 Fungal nail infections
Clinical Stage 3
 Unexplained severe weight loss (>10% of presumed or measured body weight)
 Unexplained chronic diarrhea for longer than 1 month
 Unexplained persistent fever (above 37.6°C intermittent or constant, for longer than 1 month)
 Persistent oral candidiasis
 Oral hairy leukoplakia
 Pulmonary tuberculosis (current)
 Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis or bacteremia)
 Acute necrotizing ulcerative stomatitis, gingivitis, or periodontitis
 Unexplained anemia (<8 g/dL), neutropenia (<0.5×109 per liter) or chronic thrombocytopenia (<50×109 per liter)
Clinical Stage 4
 HIV wasting syndrome
 Pneumocystis pneumonia
 Recurrent severe bacterial pneumonia
 Chronic herpes simplex infection (orolabial, genital, or anorectal of more than 1 month's duration or visceral at any site)
 Esophageal candidiasis (or candidiasis of trachea, bronchi or lungs)
 Extrapulmonary tuberculosis
 Kaposi's sarcoma
 Cytomegalovirus infection (retinitis or infection of other organs)
 Central nervous system toxoplasmosis
 HIV encephalopathy
 Extrapulmonary cryptococcosis including meningitis
 Disseminated non-tuberculous mycobacterial infection
 Progressive multifocal leukoencephalopathy
 Chronic cryptosporidiosis (with diarrhea)
 Chronic isosporiasis
 Disseminated mycosis (coccidiomycosis or histoplasmosis)
 Recurrent non-typhoidal Salmonella bacteremia
 Lymphoma (cerebral or B-cell non-Hodgkin) or other solid HIV-associated tumors
 Invasive cervical carcinoma
 Atypical disseminated leishmaniasis
 Symptomatic HIV-associated nephropathy or symptomatic HIV-associated cardiomyopathy