Table 1.
WHO Clinical Conditions or Symptoms for Adults and Adolescents with Confirmed HIV Infection12
| Clinical Stage 1 |
| Asymptomatic |
| Persistent generalized lymphadenopathy |
| Clinical Stage 2 |
| Moderate unexplained weight loss (<10% of presumed or measured body weight) |
| Recurrent respiratory tract infections (sinusitis, tonsillitis, otitis media, and pharyngitis) |
| Herpes zoster |
| Angular cheilitis |
| Recurrent oral ulceration |
| Papular pruritic eruptions |
| Seborrhoeic dermatitis |
| Fungal nail infections |
| Clinical Stage 3 |
| Unexplained severe weight loss (>10% of presumed or measured body weight) |
| Unexplained chronic diarrhea for longer than 1 month |
| Unexplained persistent fever (above 37.6°C intermittent or constant, for longer than 1 month) |
| Persistent oral candidiasis |
| Oral hairy leukoplakia |
| Pulmonary tuberculosis (current) |
| Severe bacterial infections (such as pneumonia, empyema, pyomyositis, bone or joint infection, meningitis or bacteremia) |
| Acute necrotizing ulcerative stomatitis, gingivitis, or periodontitis |
| Unexplained anemia (<8 g/dL), neutropenia (<0.5×109 per liter) or chronic thrombocytopenia (<50×109 per liter) |
| Clinical Stage 4 |
| HIV wasting syndrome |
| Pneumocystis pneumonia |
| Recurrent severe bacterial pneumonia |
| Chronic herpes simplex infection (orolabial, genital, or anorectal of more than 1 month's duration or visceral at any site) |
| Esophageal candidiasis (or candidiasis of trachea, bronchi or lungs) |
| Extrapulmonary tuberculosis |
| Kaposi's sarcoma |
| Cytomegalovirus infection (retinitis or infection of other organs) |
| Central nervous system toxoplasmosis |
| HIV encephalopathy |
| Extrapulmonary cryptococcosis including meningitis |
| Disseminated non-tuberculous mycobacterial infection |
| Progressive multifocal leukoencephalopathy |
| Chronic cryptosporidiosis (with diarrhea) |
| Chronic isosporiasis |
| Disseminated mycosis (coccidiomycosis or histoplasmosis) |
| Recurrent non-typhoidal Salmonella bacteremia |
| Lymphoma (cerebral or B-cell non-Hodgkin) or other solid HIV-associated tumors |
| Invasive cervical carcinoma |
| Atypical disseminated leishmaniasis |
| Symptomatic HIV-associated nephropathy or symptomatic HIV-associated cardiomyopathy |